By Renaldo Pool, BHSc
The Dopamine Menu concept outlines various pleasurable activities, likened to items on a menu, that are believed to enhance dopamine stimulation and support different cognitive functions in the brain.
Introduction
As a scientist and avid social media user, I always keep my eyes peeled for the next big health-conscious craze while scrolling through the multitude of images and videos we are bombarded with daily.
While scrolling one afternoon, I noticed the words “Dopamine Menu” flash across the screen, accompanied by aesthetic images of different activities – activities that resonated with me, and it immediately piqued my interest. I was thrilled; on the screen were suggestions for hobbies that I find enjoyable, and if these hobbies directly influence my dopamine levels, why wouldn’t I jump in and start boosting my mental health?
I was intrigued to explore the concept of the Dopamine Menu. This article provides insights into the biological aspects of neurotransmitter hormones and the advantages of boosting motivation, regulating emotions, and enhancing cognitive function. It also emphasizes important challenges and presents practical ways to incorporate dopamine-stimulating activities in moderation into our daily routines.
Key Takeaways
The Dopamine Menu Concept was initially introduced as an aid for individuals with ADHD to regulate their dopamine levels through pleasurable activities but has since been implemented by different populations for its benefits.
Dopamine drives motivation, modulates emotions, and enhances cognitive processes such as improving focus, working memory, and executive memory functions.
It also affects and is simultaneously influenced by other neurotransmitter hormones, which form a delicate interplay contributing to cognitive function.
The Dopamine Menu provides a personalized approach to structuring joyful activities based on your energy level and specific needs that advance overall mental well-being.
Implementing the Dopamine Menu concept should be done in moderation and be mindful of its use as a broader approach to managing mental health alongside other well-established therapeutic interventions.
How was the Dopamine Menu created?
Jessica McCabe conceptualized the idea via her YouTube Channel, “How to ADHD,” in 2020. Initially, it was aimed at individuals with ADHD to regulate their dopamine release by engaging in activities that promote a steady state of this neurotransmitter as a method of increasing productivity and enhancing focus. It has since gained traction as people from various backgrounds adopt it for its benefits, such as emotional regulation, increased productivity, and the added advantage of personalizing their daily routines with enjoyable activities. This also contributes to cognitive engagement, memory enhancement, and overall mental well-being (Kesner, 2024; Wachsman, 2025).
This concept can also be linked to the well-known Behavioral Activation (BA) therapeutic approach, which aligns with cognitive behavioral therapy (CBT). In BA, reward-system stimulation is implemented to counter depressive episodes and anxiety. BA also promotes problem-solving abilities and seeks to prevent the avoidance of activities that would otherwise contribute to depressive episodes (Psychology Today, n.d.; Psychology Tools, 2024).
Understanding the Biochemistry of Dopamine
Dopamine Synthesis and Release
The synthesis, release, and regulation of dopamine is a well-known and established process, also known for its complexity, contributing to overall cognitive function, driving motivation, and cultivating emotional balance (Watson, 2024). The interplay between dopamine and other neurocognitive hormones plays a crucial role in neural function, especially in normal and abnormal conditions (Ranjbar-Slamloo & Fazlali, 2020).
L-phenylalanine becomes L-tyrosine as it is converted by an enzyme, phenylalanine hydroxylase. Then, tyrosine hydroxylase converts tyrosine to L-3,4-dihydroxyphenylalanine or L-DOPA (Watson, 2024). This is known as a rate-limiting step of dopamine synthesis, which also means that it is the slowest step in a metabolic process that requires the most activation energy and determines the overall rate of other reactions in a pathway (MacDonald et al., 2024). L-DOPA is converted to dopamine through a decarboxylation process by L-amino acid decarboxylase (MacDonald et al., 2024; Watson, 2024).
The dopamine generation is localized to the adrenal glands and the mid-brain regions. It is stored in vesicles inside dopaminergic neurons located in the ventral tegmental area (VTA) and the substantia nigra. When stimuli reach the presynaptic terminal, dopamine-containing vesicles packaged by the vesicular monoamine transporter (VMAT2) it is released into the synaptic cleft through neuronal firing (Boyle et al., 2024; MacDonald et al., 2024).
Two modes of dopamine release exist, whereby tonic release refers to the consistent and slow secretion of dopamine, characterized by the upkeep of baseline dopamine levels in the brain. The release is maintained at low intervals (1-4 Hz), providing mood and cognitive regulation. Phasic release occurs with short bursts of high-frequency (10-30 Hz) secretion due to new or rewarding stimuli. The latter method of dopamine release is essential for response to rewards or strengthening behavior linked with reward-giving stimuli (Boyle et al., 2024; MacDonald et al., 2024).
Dopamine Regulation
Specific ion channels, such as KV4.3 and BKCa1.1, have been implicated in dopamine neuron firing patterns and their regulation. A recent study found that these channels influence motivation and learning behavior in animal models. This further improves cognitive function, providing therapeutic target identification for disorders like depression and learning disabilities (Boyle et al., 2024; MacDonald et al., 2024).
Dopamine is removed from the synaptic cleft through reuptake mechanisms by stimulating postsynaptic receptors. The dopamine transporter (DAT) molecule controls this process. In this manner, dopamine signaling is inhibited and recycled for later use (Boyle et al., 2024; MacDonald et al., 2024).
Dopamine is further regulated through feedback mechanisms, whereby auto receptors or presynaptic neurons are stimulated to continue or inhibit the release by receiving feedback on the concentration of extracellular dopamine available. This provides homeostasis of dopamine signaling (Chakroun et al., 2023; MacDonald et al., 2024).
Dopamine’s role in biological systems
This neurotransmitter plays a role not only in emotional regulation, driving motivation, and enhancing cognition but also contributes to coordinating voluntary movements through the substantia nigra to the striatum pathway (Ahmadi et al., 2023).
Dysregulation of dopamine in these various pathways in the brain leads to possible motor control disorders, such as Parkinson’s disease, as well as depression, anxiety, and schizophrenia (Ranjbar-Slamloo & Fazlali, 2020; Boyle et al., 2024).
The VTA is connected to various areas in the mesolimbic pathway, such as the nucleus accumbens. This contributes to reward processing activities and enhances motivational drive. It further strengthens reward-seeking behavior and plays a role in decision-making and learning (Ranjbar-Slamloo & Fazlali, 2020; Ahmadi et al., 2023; Yang et al., 2023; Boyle et al., 2024). Dopamine is associated with different cognitive functions, such as working memory, attention, and executive function. It regulates the neural circuits by actively participating in these cognitive processes, improving cognitive flexibility and solidifying working memory processing (Ranjbar-Slamloo & Fazlali, 2020; Ahmadi et al., 2023; Boyle et al., 2024).
Dopamine also plays an integral role in regulating emotions, and increased levels contribute to an overall improved mood and enhance motivation (Leranza et al., 2021; Boyle et al., 2024).
The Relationship Between Dopamine and Other Neurostimulator Hormones
Alongside other neurostimulator hormones such as cortisol, norepinephrine, serotonin, and glutamate, dopamine’s impact on cognition and emotional regulation is essential for a variety of reasons:
Neurostimulator | Effect | Dysregulation |
Norepinephrine (Noradrenaline) | Enhances focus, arousal, stress response, emotional regulation, and cognitive flexibility. It also partakes in how the body reacts in a flight-or-fight response. Improves dopamine's effect on motivation and attention. Involved in synaptic transmission and plasticity in areas like the prefrontal cortex and hippocampus.
It also plays a role in the long-term potentiation (LTP) (the strengthening of neuronal connections due to regular activation) of dopaminergic pathways essential for memory consolidation and learning (Ranjbar-Slamloo & Fazlali, 2020; Boyle et al., 2024). | Dysregulation in ADHD leads to impaired attention and increased impulsivity due to insufficient norepinephrine-dopamine signaling. |
Cortisol | During stress-induced scenarios, this glucocorticoid hormone is secreted by the hypothalamic-pituitary-adrenal (HPA) axis, contributing to different brain regions such as the hippocampus and prefrontal cortex. These two areas are essential for building and maintaining memory and executive functions (Henry et al., 2021; Dresp-Langley, 2023). | Chronic stress leads to decreased dopamine receptor sensitivity, negatively affects dopamine signaling, and elevates stress induction. The effect is impairment of memory consolidation and retrieval, contributing to conditions like depression. |
Serotonin | Regulates mood and cognitive flexibility. Inhibits dopamine activity, as serotonin lesions increase dopamine neuron firing rates. These neurotransmitters have an inhibitory relationship, where serotonin lesions have been noted to increase the dopamine neuron firing rate from the VTA (Boyle et al., 2024). | Disrupted release affects cognition and emotional stability, contributing to conditions like schizophrenia. |
Glutamate | The primary excitatory neurotransmitter involved in synaptic plasticity, memory, and learning, influencing processes such as LTP and long-term depression (LTD), which refers to the strengthening and weakening of neural connections respectively (Speranza et al., 2021). Dopamine activation influences glutamate release in the prefrontal cortex, affecting working memory and higher-order thinking (Yang et al., 2023). | Dysregulation in dopamine-glutamate pathways is associated with psychiatric disorders like schizophrenia and addiction. |
Table 1: This table discusses the roles of different neurotransmitters and hormones in cognitive processes and their potential dysregulation in various conditions.
Altogether, these neurostimulator hormones’ interplay with dopamine provides optimal cognitive functioning in healthy individuals.
Dopamine’s Influence on Cognitive Processes
The influence of dopamine-stimulating activities has recently been investigated to gauge their impact on mood regulation, motivation, decision-making approaches, and cognition.
Motivation and Effort
Dopamine-stimulating activities determine whether individuals will engage in certain activities based on their required effort. Higher dopamine levels are associated with individuals focusing on the rewards gained from challenging tasks instead of the difficulty level. This indicates that it promotes motivation to engage in cognitive-challenging activities, builds resilience, and drives consistent engagement and input (Westbrook & Braver, 2016; Westbrook et al., 2020; Boyle et al., 2024).
Cognitively flexible
Individuals can adapt their thinking and behavior during challenging situations by modulating dopamine activity with a Dopamine Menu. Structured activities, provided by a customized Dopamine Menu, allow individuals to cultivate a decision-making process that is fast, reliable, and accurate (Westbrook et al., 2020; Leow et al., 2024).
Learning and Skills Gain
Dopamine plays a role in learning through the associations between stimuli and rewards. A previous study indicated increased dopamine availability during training improved accuracy and reaction times for more complex tasks. This suggests that a dopamine menu can improve learning outcomes by strengthening skill-building through motivation (Chakroun et al., 2023; Leow et al., 2024).
Physical exercise and Cognition
Using a dopamine menu to regulate dopamine release affects one’s perception of effort during physical activity, further influencing motivation and engagement. Higher dopamine levels are associated with increased participation in physical exercise or tasks because people perceive them as easier. Physical activities also improve cognitive function by improving mood and mental clarity (Chakroun et al., 2023; Healthdirect Australia, 2023).
Implementing the Dopamine Menu in Real-World Scenarios
The Dopamine Menu suggests dopamine-boosting activities grouped by engagement level, providing a tailored approach depending on an individual’s energy level and current emotional state.
Dopamine-inducing activities are divided between appetizers, entrées, sides, desserts, and specials. Using different meals on a menu is a clever way of engaging individuals. It provides a structured approach with various options to suggest the best dopamine-fueled activities (Wachsman, 2025).
Appetizers on the dopamine menu should include rapid, low-effort activities that stimulate immediate reward. Examples include watching a funny video, meditation, a quick-burn cardio exercise, doodling, or standing in the sun.
Entrees are more engaging approaches requiring moderate effort, such as having dinner with a friend or family, watching a movie, walking, or listening to a song.
Sides are associated with supportive tasks that aid in one’s involvement with more challenging activities. Examples include listening to a podcast or audiobook, calling or texting a friend, or lighting a candle for aromatherapy.
Desserts are indulgent, and enjoying these activities in moderation is essential, such as playing a video game, binge-watching a TV show, and ordering takeout.
Specials are tasks that are considered more costly and require more effort to perform. They include activities such as treating yourself to a meal at a restaurant, buying a new piece of clothing, or watching a live concert.
By using these varieties of options and creating a customized dopamine menu based on your needs and emotional state, you can positively contribute to your overall mental well-being.
The Dopamine Menu: Benefits and Challenges to Consider
Benefits:
Adding activities to your daily routine, or as needed, that you enjoy enhances dopamine release, drives motivation for reward-seeking opportunities, and is essential for cognition. Engaging in stimulating activities that you prefer can mitigate feelings of lethargy (low energy), disruption of focus, sadness, and anxiety.
The Dopamine Menu’s various stimulating activity options provide a structured way of deciding what activities to incorporate as needed. This decreases decision fatigue, especially for individuals overwhelmed with too many choices.
Participating in pleasurable tasks improves emotional well-being, decreases stress levels, and prevents inertia or lack of motivation. It provides individuals with tools for activating energy and enabling them to initiate less appealing tasks with a newfound approach.
When implemented in moderation, the Dopamine Menu profoundly affects long-term cognitive function. It builds resilience against stressful situations and improves overall mental health.
With different reward-providing tasks incorporated into your daily life, albeit small, you create a more positive mindset.
It is also easy to adapt and change the Dopamine Menu to fit your needs and what resonates with you most. It ensures versatility for individuals, with various options that are easy and provide consistent integration into their daily lives.
The ease of access and implementation of a Dopamine Menu are user-friendly for individuals from different backgrounds. It provides a structured approach to improving mental well-being, productivity, and motivation.
Challenges:
Implementing a dopamine menu in one’s daily life should not be seen as a replacement for adjunct therapeutic options. It is merely a suggested approach to aid mood regulation and motivation, especially for challenging or mediocre tasks. Suppose adherence to a dopamine menu becomes difficult as a result of underlying conditions, such as anxiety or depression. In that case, it should not be dismissed, and a healthcare professional should be consulted.
If individuals prefer or over-indulge in activities that release high amounts of dopamine without moderation, they may experience habituation or reduced satisfaction over time. This cultivates the habit of seeking even higher dopamine-releasing activities, resulting in meaningful experiences losing their lackluster (Dresp-Langley, 2023; Desai et al., 2024).
When an individual’s dependency becomes rooted in external rewards to drive motivation, self-regulation and intrinsic motivation become challenging.
The Dopamine Menu promotes engagement in meaningful and enjoyable activities. However, it could lead to individuals seeking instant gratification through implementing short-term dopamine fixes that contrast the long-term and committed patience required for sustainable dopamine stimulation.
By implementing too frequent high-dopamine release activities, the effect on an individual’s overall emotional state becomes disrupted, as excess dopamine stimulation can cause increased anxiety, impulsivity, and irritability symptoms. This, in turn, creates a risk for people with existing psychological conditions (Silva, 2024).
Although the Dopamine Menu has garnered attention in society and consists of easy-to-do practical approaches, its impact has not yet been thoroughly investigated. Limited scientific evidence is available to validate it as a go-to method for improving motivation and cognitive function, regulating mood disorders, or treating other psychiatric conditions. Further investigation is required to establish its efficacy and assess the outcomes, especially for treatment-related neurocognitive disorders.
Conclusion
Dopamine plays an integral role in neurofunctional processes. It is influenced by and regulates other neurostimulator hormones, contributes to emotional control and mental health, improves cognitive functions, and elevates a person’s motivational drive.
Although the Dopamine Menu concept can easily and moderately be integrated into daily life, considering its benefits and challenges, future research must substantiate the efficacy of natural dopamine-boosting activities since its impact has not been thoroughly investigated.
A better understanding of dopamine's functional processes, alongside the influence of other essential neurostimulator hormones, can ensure a thorough, long-term investigation of its impact. This, in turn, can contribute to the consideration of establishing or improving targeted therapeutic options to address the shortcomings in specific psychiatric disorders regarding dopamine stimulation and regulation seen today.
References
1. Ahmadi, M., Rouhi, N., Fathollahi, Y., Shojaei, A., Rezaei, M., Rostami, S., Saab, B. J., & Mirnajafi-Zadeh, J. (2023). A dual effect of dopamine on hippocampal LTP and cognitive functions in control and kindled mice. Journal of Neuroscience, 44(5), e0926212023. https://doi.org/10.1523/jneurosci.0926-21.2023
2. Behavioral activation. (n.d.). Psychology Today. https://www.psychologytoday.com/za/therapy-types/behavioral-activation
3. Boyle, N., Betts, S., & Lu, H. (2024). Monoaminergic Modulation of Learning and Cognitive Function in the Prefrontal Cortex. Brain Sciences, 14(9), 902. https://doi.org/10.3390/brainsci14090902
4. Chakroun, K., Wiehler, A., Wagner, B., Mathar, D., Ganzer, F., Van Eimeren, T., Sommer, T., & Peters, J. (2023). Dopamine regulates decision thresholds in human reinforcement learning in males. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-41130-y
5. Desai, D., Patel, J., Saiyed, F., Upadhyay, H., Kariya, P., & Patel, J. (2024). A Literature Review on Holistic Well-Being and Dopamine Fasting: An Integrated Approach. Cureus, 16(6), e61643. https://doi.org/10.7759/cureus.61643
6. Dresp-Langley, B. (2023). From Reward to Anhedonia-Dopamine Function in the Global Mental Health Context. Biomedicines, 11(9), 2469. https://doi.org/10.3390/biomedicines11092469
7. FreePik.com. (2024). https://www.freepik.com/search?ai=only&format=search&last_filter=page&last_value=2&page=2&query=dopamine+brain+synapse+reward+system&selection=1&type=photo#uuid=89ad3dd0-cd1d-494f-8a50-d86337427f6c
8. Healthdirect Australia. (2023). Dopamine. Healthdirect. https://www.healthdirect.gov.au/dopamine
9. Henry, M., Thomas, K. G. F., & Ross, I. L. (2021). Sleep, cognition and cortisol in Addison’s Disease: a mechanistic relationship. Frontiers in Endocrinology, 12. https://doi.org/10.3389/fendo.2021.694046
10. Kesner, R. (2024). Mind Lab Pro® Universal Nootropic. Mind Lab Pro®. https://www.mindlabpro.com/blogs/nootropics/dopamine-menus-how-to-fuel-your-focus#the-neuroscience-of-motivation
11. Leow, L., Bernheine, L., Carroll, T. J., Dux, P. E., & Filmer, H. L. (2024). Dopamine increases accuracy and lengthens deliberation time in explicit motor skill learning. eNeuro, 11(1), ENEURO.0360-23.2023. https://doi.org/10.1523/eneuro.0360-23.2023
12. MacDonald, H. J., Kleppe, R., Szigetvari, P. D., & Haavik, J. (2024). The dopamine hypothesis for ADHD: An evaluation of evidence accumulated from human studies and animal models. Frontiers in Psychiatry, 15. https://doi.org/10.3389/fpsyt.2024.1492126
13. Nieoullon, A. (2002). Dopamine and the regulation of cognition and attention. Progress in neurobiology, 67(1), 53–83. https://doi.org/10.1016/s0301-0082(02)00011-4
14. Psychology Tools. (2024). Using Behavioral Activation to Overcome Depression | Psychology Tools. https://www.psychologytools.com/self-help/behavioral-activation
15. Ranjbar-Slamloo, Y., & Fazlali, Z. (2020). Dopamine and noradrenaline in the brain; overlapping or dissociate functions? Frontiers in Molecular Neuroscience, 12. https://doi.org/10.3389/fnmol.2019.00334
16. Silva, S. (2024, October 10). What is the role of dopamine in ADHD? Healthline. https://www.healthline.com/health/adhd/adhd-dopamine
17. Speranza, L., di Porzio, U., Viggiano, D., de Donato, A., & Volpicelli, F. (2021). Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control. Cells, 10(4), 735. https://doi.org/10.3390/cells10040735
18. Wachsman, M. W. (2025, January 14). Using a dopamine menu to stimulate your ADHD brain. ADDitude. https://www.additudemag.com/dopamenu-dopamine-menu-adhd-brain/
19. Watson, S. (2024, April 18). Dopamine: The pathway to pleasure. Harvard Health. https://www.health.harvard.edu/mind-and-mood/dopamine-the-pathway-to-pleasure
20. Westbrook, A., & Braver, T. S. (2016). Dopamine Does Double Duty in Motivating Cognitive Effort. Neuron, 89(4), 695–710. https://doi.org/10.1016/j.neuron.2015.12.029
21. Westbrook, A., van den Bosch, R., Määttä, J. I., Hofmans, L., Papadopetraki, D., Cools, R., & Frank, M. J. (2020). Dopamine promotes cognitive effort by biasing the benefits versus costs of cognitive work. Science (New York, N.Y.), 367(6484), 1362–1366. https://doi.org/10.1126/science.aaz5891
22. Yang, J., Basu, A., Liu, R., Staszko, S. M., Yu, A. L., Rondeau, J., Glaeser-Khan, S., Feng, J., Li, Y., Che, A., & Kaye, A. P. (2023). Frontal cortex norepinephrine, serotonin, and dopamine dynamics in an innate fear-reward behavioral model. bioRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.1101/2023.11.27.568929
About Renaldo Pool, BHSc
As a Medical Laboratory Scientist, I've developed a passion for scientific research and writing. I combine theory and practice to explore healthcare advancements. My lab expertise helps me investigate areas for improvement in healthcare through research and practical implementation. I aim to conduct thorough studies to advance medical knowledge and aid healthcare professionals in decision-making. Ultimately, I strive to bridge the gap between research and application for a positive impact in the healthcare profession.
